Sustainable Fat Loss | Keto Long Term Results | Wire Your Brain for Weight Loss [gQPxrSMXeO6]

Sustainable Fat Loss | Keto Long Term Results | Wire Your Brain for Weight Loss [gQPxrSMXeO6]

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Click Here to Subscribe: My Special Fan Discount on Four Sigmatic: Website: Sustainable Fat Loss | Keto Long Term Results | Wire Your Brain for Weight Loss… The hypothalamus is gland in your body that is responsible for secreting hormones - this also communicates with your pituitary gland and your adrenals, otherwise known as your hypothalamic, pituitary, adrenal (or HPA) axis. The hypothalamus is a source of neural progenitor cells which give rise to different populations of specialized and differentiated cells during brain development. Newly formed neurons in the hypothalamus can synthesize and release various neuropeptides - hypothalamic neuropeptides remain major signaling molecules mediating short- and long-term effects on brain development. They represent important factors in neurite growth and formation of neural circuits - there is evidence suggesting that the newly generated hypothalamic neurons may be involved in regulation of metabolism, energy balance, body weight, and social behavior as well. Ketosis & Hypothalamic Neuropeptides: Hypothalamic neuropeptides become extremely elevated on a ketogenic diet, with a study published in the American Journal of Physiology finding that mice put on a keto diet rapidly lost weight and, surprisingly, the expression of several neuropeptides known to influence feeding and energy expenditure was consistent with the fall in leptin levels resulting from weight loss. *Ketosis increased the amount of neuropeptides - hypothalamic neuropeptides are great at hypothalamic stimulation and ketones can cross the blood-brain barrier, and signal these neuropeptides* Neuropeptides & Neurogenesis: The generation of new cells in the brain has been proved under influence of certain neuropeptides. Neuropeptide oxytocin has been reported to stimulate neurogenesis in the adult hippocampus. Moreover, oxytocin may also affect expression of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which represent important regulators of neuronal function. *The link I’m trying to make here is that keto can elevate neuropeptides, which normally stimulate neurogenesis and BDNF, so by increasing neuropeptides you *may* increase neurogenesis and increase expression of BDNF* Neuropeptides & Autophagy There’s a bunch of different types of neuropeptides that are involved in autophagy - they are increased during autophagy - so by increasing neuropeptides via ketosis, there may be a more profound effect in regards to autophagy. For example, substance P (SP) belongs to tachykinins family, which includes neuropeptides expressed in neuronal and in nonneuronal cells - among its multiple roles, SP was recently associated with increased autophagy. Additionally, orexins (or hypocretins) are hypothalamic neuropeptides that regulate arousal, wakefulness, and appetite - orexin A has been shown to induce the formation of autophagic vacuoles. References: 1) physiology.org | Error. (n.d.). Retrieved from 2) The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis. (2016, January 13). Retrieved from 3) Current Evidence for a Role of Neuropeptides in the Regulation of Autophagy. (n.d.). Retrieved from 4) The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis. (2016, January 13). Retrieved from