180 - AMA #28 [sneak peek]: All things testosterone and testosterone replacement therapy [zUFwfKNW1i5]

180 - AMA #28 [sneak peek]: All things testosterone and testosterone replacement therapy [zUFwfKNW1i5]

| 1h 28m 28s | Video has closed captioning.

In this “Ask Me Anything” (AMA) episode, Peter and Bob discuss all things related to testosterone: what happens when testosterone levels are low, and the potential benefits and risks of testosterone replacement therapy (TRT). They explain the physiology of testosterone, how it works, and how its level changes over the course of a person's life. They have a detailed discussion about existing literature, which reveals vast potential structural, functional, and metabolic benefits of testosterone replacement therapy. They also take a very close look at potential risks of this therapy, with a focus on the controversial effects on cardiovascular disease and prostate cancer. In this sneak peek, we discuss: 00:00 - Intro 00:10 - A primer on the hormone testosterone and how it influences gene expression 09:00 - How the body naturally regulates testosterone levels In the full episode, we also discuss: -The defining threshold for "low testosterone," how low T impacts men, and why free testosterone is the most important metric; -When it makes sense to treat low testosterone; -The structural and metabolic benefits of testosterone replacement therapy; -Body composition changes with TRT; -Changes in bone mineral density with TRT; -The metabolic impact of TRT: glucose, insulin, triglycerides, and more; -A study investigating testosterone replacement therapy for prevention or reversal of type 2 diabetes; -The impact of TRT on metabolic parameters and body composition—A study comparing results from continuous vs. interrupted treatment; -The controversy over TRT and cardiovascular disease; -Two flawed studies that shaped perceptions of risks associated with TRT; -The controversy over TRT and prostate cancer; -Other potential risks with testosterone replacement therapy; and -More Show notes page: -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: Subscribe to receive exclusive subscriber-only content: Sign up to receive Peter's email newsletter: Connect with Peter on: Facebook: Twitter: Instagram: Subscribe to The Drive: Apple Podcast: Overcast: Spotify: Google Podcasts: